Healthcare

Alnylam Pharmaceuticals (ALNY)

$223.82 −1.4% on the day·−51.9% in a year·close Oct 13, 2026

In the Nasdaq-100.

Your signal

Sell7 / 100

Sell: 7 is at or below your Sell line of 40. Plays in (13%) scores 13 and lifts it; Off the high (−54% from its 1-year high) scores 0 and holds it back.

Every factor in this score has a tested record: each was checked month by month since 2011 on numbers public at the time.

Factor you weight	ALNY	Points	Weight	Adds
Plays in	13%	13	40	5.2
Off the high	−54% from its 1-year high	0	30	0.0
Trend	−25% vs 200-day	6	30	1.8

Email me when it flips

Your signal is the one call Be The Puck makes on a stock, and you set it: weight the plays, analysts, P/E, growth, debt, trend and more, and move the Buy and Sell lines. Every page follows your choice. How the score works

All 18 factors for ALNY

Factor	ALNY	Points	What it is
Plays in	13%	13	The share of the plays you count that hold it now.
Analysts' upside	+66% · 26 analysts · capped: below 200-day	50	How far analysts' average 12-month target sits above the price (3+ analysts). −20% scores 0, +50% full marks; at most 50 while the price is below its 200-day average, since targets lag a falling price.
Analysts' rating	1.7 · buy	66	The analysts' average recommendation: strong buy scores 100, hold or worse 0.
P/E	37.7×	28	Price over the last four quarters' earnings per share. Lower ranks higher; a loss scores 0. Source: Yahoo Finance.
Forward P/E	17.9×	42	Price over next year's expected earnings. Lower ranks higher; an expected loss scores 0. Source: Yahoo Finance.
PEG	0.32	92	P/E divided by expected earnings growth. Lower ranks higher; around 1 is often read as fair for the growth. Source: Yahoo Finance.
Price to sales	6.2×	27	Market value over the last 12 months' revenue. Lower ranks higher. Source: Yahoo Finance.
Price to book	22.1×	6	Price over book value (assets minus debts) per share. Lower ranks higher. Source: SEC filings to 2026-06-30.
Dividend yield	none	0	Dividends over the last year as a share of the price. Higher ranks higher; no dividend scores 0. Source: Yahoo Finance.
Earnings growth	–	–	Earnings per share over the last four quarters against the four before (the latest quarter on a year earlier where filings aren't available). Higher ranks higher.
Revenue growth	+67%	90	Revenue over the last four quarters against the four before (the latest quarter on a year earlier where filings aren't available). Higher ranks higher. Source: Yahoo Finance.
Profit margin	16%	60	Net profit as a share of revenue. Higher ranks higher. Source: Yahoo Finance.
Return on equity	60%	94	Profit as a share of shareholders' equity. Higher ranks higher. Source: SEC filings to 2026-06-30.
Debt to equity	0.50×	52	Debt against shareholders' equity. Lower ranks higher; negative equity scores 0. Source: SEC filings to 2026-06-30.
Off the high	−54% from its 1-year high	0	How far the price sits below its highest close of the last year: 100 points at the high, none at 30% or more below. The exit rule: a stock that keeps falling loses points whatever else it has going for it.
Trend	−25% vs 200-day	6	How far the price sits above its 200-day average. Higher ranks higher.
1-year momentum	−52%	5	The price change over the last 12 months. Higher ranks higher.
Low crash exposure	4/10 · moderate	60	The storm test: 100 for no exposure, 10 points off per point of exposure.

The read

Test a theory on ALNY

13 of the 100 plays hold ALNY right now.
The trend-following, breakout, momentum, volume and pattern plays mostly say out.
It closed 25% below its 200-day average and 54% below its 52-week high.
Crash exposure reads moderate: it carries 3.8× as much debt as equity and operating profit covers interest only 2.3×.
Analysts' average 12-month target is $370.55, 66% above the close (26 analysts).

This analysis does not constitute trading advice. Please meet with an advisor or independently review sources before making any decision. New to this? Start with the basics.

Plays in13 / 100Every play Be The Puck tests, in 7 families.

Crash exposureModerate4 of 10 on the storm test Mayer Multiple0.75×Price ÷ its 200-day average (−25%). Higher than on 8% of days since 2005. Above 2.4 is Mayer's overheated zone.

The most accurate play in each family

Each family's play whose calls went the right way most often, tested on 351 stocks since 2005, and what it says about ALNY now.

Trend followingHoly GrailOUT42% of 12,813 calls rightOn ALNY: right 21 of 47 · Out since Oct 30, 2025 Breakouts & channelsP&F Double TopOUT37% of 36,314 calls rightOn ALNY: right 76 of 233 · Out since Oct 1, 2026 Momentum12-1 MomentumOUT44% of 8,156 calls rightOn ALNY: right 6 of 18 · Out since Jun 30, 2026 Mean reversionBollinger ReversionIN64% of 53,095 calls rightOn ALNY: right 108 of 173 · In since Oct 1, 2026 Volume & money flowMoney Flow IndexOUT59% of 13,925 calls rightOn ALNY: right 30 of 52 · Out since Jul 10, 2026 Candles & chart patternsEngulfing SwitchOUT50% of 38,976 calls rightOn ALNY: right 76 of 161 · Out since Jun 10, 2026 CalendarHalloween IndicatorOUT54% of 12,345 calls rightOn ALNY: right 19 of 43 · Out since Apr 30, 2026

A call is right when the stock rose after an in call or fell after an out call. Trend plays are built to take many small losses for a few big wins, so their hit rates run lower; being right often isn't the same as making the most money. How we test a play.

ALNY, day by day

How to read candlesticks

Each candle is one trading day: the box spans the open and close, the thin line the day's high and low. Hollow boxes closed up, filled boxes closed down. Toggle the averages to see the trend the plays read. Dots above the candles mark news and company filings: hover or tap one to see the story and how the stock moved from the last close before it, against the market on the same days.

What moved ALNY lately

No session in the last 30 moved it twice a normal day against the S&P 500; these were its largest, the news read on each, and how reliably that kind of news has moved stocks before. How it's measured

Fri Oct 2−5.7% against the S&P 5001.1× a normal day

ALNY −5.0%, the S&P 500 +0.7% that session; −4.2% against the S&P 500 over five sessions.

HeadlineStock Titan · Oct 2, 3:46 pm ET
An Alnylam (ALNY) officer proposes a $399K share sale that includes shares to cover an equity-award tax bill.
HeadlineSimply Wall Street · Oct 2, 1:25 am ET
Alnylam Pharmaceuticals (ALNY) Stock Looks Above Fair Value As Shares Fell 49%

Thu Oct 1−6.5% against the S&P 5001.3× a normal day

ALNY −6.3%, the S&P 500 +0.2% that session; −11.0% against the S&P 500 over five sessions.

No earnings report, rating change, 8-K filing or news story on ALNY was found for this session. Be The Puck's headline archive for ALNY starts Oct 2, so news stories from that day aren't in it. The S&P 500 moved +0.2%. The 17 other Healthcare stocks Be The Puck covers moved −1.5% on average, so most of the move was its own.

Wed Sep 2+8.2% against the S&P 5001.7× a normal day

ALNY +8.7%, the S&P 500 +0.5% that session; +4.8% against the S&P 500 over five sessions.

No earnings report, rating change, 8-K filing or news story on ALNY was found for this session. Be The Puck's headline archive for ALNY starts Oct 2, so news stories from that day aren't in it. The S&P 500 moved +0.5%. The 17 other Healthcare stocks Be The Puck covers moved +1.3% on average, so most of the move was its own.

Next earnings report

Thu Oct 29, 2026 before the open

From Yahoo Finance's calendar; dates can move. Analysts expect earnings per share of 2.30.

Over its last 12 reports, ALNY's typical move against the S&P 500 at the first close after the report was ±3.6% (median size, either way); it finished ahead of the index 4 times.
ALNY after beats of 5% or more: ahead of its index at the first close after the report 9 of 18 times (median +0.3%).
ALNY after misses of any size: behind its index at the first close after the report 19 of 30 times (median −0.7%).
Across all covered stocks, beats of 5% or more were followed by a gain against the index 64% of the time and misses by a drop 62% of the time.

Whether a report beats is only known once it is out, so these say how the stock has reacted, not which way it will go.

Two years of calls, week by week

InOutShare of plays in

One row per play, grouped by family. When most rows turn green at once, the trend is broad. When they split, the plays disagree and the stock is usually chopping sideways.

Every play on ALNY

All 100 plays, by family.

Trend following2 of 30 in Breakouts & channels0 of 15 in Momentum0 of 17 in Mean reversion7 of 15 in Volume & money flow0 of 9 in Candles & chart patterns0 of 3 in Calendar4 of 11 in

Calls right: how often the play's calls on ALNY went the right way since 2005. Record columns: play / buy and hold, annual return and worst drawdown since 2005. Click a column to sort.Sort with the menu above the list.

Play	Call	Since	Next move	Calls right	Annual return	Worst drawdown
Trend following
PB EMABitcoin Playboy · daily	OUT	Sep 30, 2026 −9.3%	Enter above $235.23 (+5.1%)	27% 178/649	+5.1% / +16.9%	−72.5% / −83.6%
Bull Market Support BandBenjamin Cowen · weekly	OUT	Dec 12, 2025 −43.7%	Enter above $260.78 (+16.5%)	26% 29/111	+1.1% / +17.2%	−89.0% / −83.6%
Ripster EMA CloudRipster · daily	OUT	Sep 30, 2026 −9.3%	Enter above $244.08 (+9.1%)	23% 89/387	+2.6% / +16.9%	−86.6% / −83.6%
Trend TemplateMark Minervini · daily	OUT	Dec 8, 2025 −48.0%	Not on one close	17% 28/166	+2.5% / +17.3%	−71.7% / −83.6%
Stage AnalysisStan Weinstein · weekly	OUT	Dec 12, 2025 −43.7%	Enter above $570.80 (+155.0%)	26% 15/57	+10.7% / +17.3%	−62.9% / −83.6%
Stage 2 + Mansfield RSStan Weinstein · weekly	OUT	Dec 12, 2025 −43.7%	Enter above $356.98 (+59.5%)	26% 16/61	+14.4% / +17.3%	−71.6% / −83.6%
10-Month SMAMeb Faber · month-end	OUT	Jan 30, 2026 −33.8%	Enter above $289.70 (+29.4%)	36% 12/33	+9.2% / +17.3%	−76.2% / −83.6%
200-Day RulePaul Tudor Jones · daily	OUT	Jan 12, 2026 −39.7%	Enter above $296.31 (+32.4%)	13% 23/173	+8.6% / +17.4%	−72.7% / −83.6%
Golden CrossMarket tradition · daily	OUT	Feb 11, 2026 −30.6%	Not on one close	32% 10/31	+5.3% / +17.4%	−73.2% / −83.6%
Granville 200-DayJoseph E. Granville · daily	OUT	Jan 12, 2026 −39.7%	Not on one close	14% 17/121	+9.2% / +16.7%	−71.0% / −83.6%
Hull Moving AverageAlan Hull · weekly	IN	Sep 4, 2026 −15.9%	Exit below $241.58 (+7.9%)	36% 49/138	+5.9% / +16.9%	−81.1% / −83.6%
Kaufman Adaptive MAPerry J. Kaufman · daily	OUT	Sep 30, 2026 −9.3%	Enter above $233.59 (+4.4%)	27% 207/777	+10.5% / +16.9%	−75.3% / −83.6%
TEMA CrossoverPatrick G. Mulloy · daily	OUT	Oct 2, 2026 +1.9%	Enter above $269.48 (+20.4%)	40% 93/234	+9.2% / +16.5%	−77.9% / −83.6%
Seykota 15/150Ed Seykota · daily	OUT	Feb 13, 2026 −28.8%	Not on one close	30% 10/33	+10.4% / +16.4%	−64.4% / −83.6%
Guppy Multiple MAsDaryl Guppy · daily	OUT	Jul 14, 2026 −20.4%	Enter above $386.81 (+72.8%)	30% 40/135	+2.2% / +16.9%	−83.3% / −83.6%
Ichimoku CloudGoichi Hosoda · daily	OUT	Jul 13, 2026 −22.3%	Not on one close	28% 35/125	+2.8% / +16.9%	−83.5% / −83.6%
SupertrendOlivier Seban · daily	OUT	Oct 2, 2026 +1.9%	Enter above $248.90 (+11.2%)	32% 52/165	+0.8% / +16.9%	−88.8% / −83.6%
Williams AlligatorBill Williams · daily	OUT	Oct 6, 2026 −0.1%	Not on one close	44% 144/329	+4.5% / +16.9%	−84.5% / −83.6%
Vortex IndicatorEtienne Botes & Douglas Siepman · daily	OUT	Sep 23, 2026 −9.2%	Enter above $273.51 (+22.2%)	34% 200/589	−0.1% / +16.9%	−87.2% / −83.6%
AroonTushar S. Chande · daily	OUT	Oct 2, 2026 +1.9%	Enter above $261.98 (+17.0%)	32% 78/243	−6.4% / +16.9%	−91.4% / −83.6%
Parabolic SARJ. Welles Wilder Jr. · daily	OUT	Sep 15, 2026 −6.1%	Enter above $233.83 (+4.5%)	38% 189/495	+7.3% / +16.9%	−74.5% / −83.6%
ADX TrendJ. Welles Wilder Jr. · daily	OUT	Jul 30, 2026 +8.9%	Not on one close	36% 63/175	−3.3% / +16.9%	−71.3% / −83.6%
MACD Zero LineGerald Appel · daily	OUT	Oct 1, 2026 −3.2%	Enter above $299.76 (+33.9%)	29% 58/203	+1.1% / +16.9%	−82.7% / −83.6%
Zweig 4% ModelMartin Zweig · weekly	IN	Oct 9, 2026 −3.8%	Exit below $223.37 (−0.2%)	38% 120/314	+10.1% / +16.9%	−64.0% / −83.6%
MAMA/FAMA CrossJohn F. Ehlers · daily	OUT	Oct 2, 2026 +1.9%	Enter above $685.00 (+206.0%)	28% 69/247	+4.6% / +16.9%	−81.3% / −83.6%
Schaff Trend CycleDoug Schaff · daily	OUT	Oct 2, 2026 +1.9%	Not on one close	42% 98/234	+8.8% / +16.5%	−64.2% / −83.6%
Zero Lag EC CrossJohn F. Ehlers & Ric Way · daily	OUT	Oct 1, 2026 −3.2%	Enter above $295.82 (+32.2%)	28% 55/197	+2.0% / +16.9%	−82.0% / −83.6%
DP Trend ModelCarl Swenlin & Erin Swenlin · daily	OUT	Jul 13, 2026 −22.3%	Enter above $393.09 (+75.6%)	32% 38/117	+2.0% / +16.9%	−79.7% / −83.6%
Elder Triple ScreenAlexander Elder · daily	OUT	Oct 2, 2026 +1.9%	Enter above $229.53 (+2.6%)	32% 63/194	+1.5% / +16.8%	−67.6% / −83.6%
Holy GrailLinda Bradford Raschke & Larry Connors · daily	OUT	Oct 30, 2025 −50.2%	Not on one close	45% 21/47	+2.5% / +16.9%	−25.6% / −83.6%
Breakouts & channels
Four-Week RuleRichard Donchian · daily	OUT	Oct 1, 2026 −3.2%	Enter above $257.27 (+14.9%)	35% 50/141	+3.8% / +16.9%	−86.8% / −83.6%
Turtle System 1Richard Dennis & William Eckhardt · daily	OUT	Oct 1, 2026 −3.2%	Enter above $257.27 (+14.9%)	33% 42/129	+4.5% / +16.9%	−60.7% / −83.6%
Turtle System 2Richard Dennis & William Eckhardt · daily	OUT	Nov 3, 2025 −48.4%	Enter above $290.60 (+29.8%)	31% 28/90	+7.9% / +16.9%	−66.6% / −83.6%
Clenow TrendAndreas F. Clenow · daily	OUT	Nov 3, 2025 −48.4%	Not on one close	26% 24/92	+4.7% / +16.9%	−79.9% / −83.6%
Darvas BoxNicolas Darvas · daily	OUT	Oct 1, 2026 −3.2%	Enter above $251.71 (+12.5%)	38% 50/133	+5.5% / +16.9%	−72.9% / −83.6%
Keltner ChannelChester W. Keltner & Linda Bradford Raschke · daily	OUT	Sep 10, 2026 −9.6%	Enter above $261.98 (+17.0%)	32% 48/148	+1.1% / +16.9%	−78.2% / −83.6%
Bollinger BreakoutJohn Bollinger · daily	OUT	Sep 15, 2026 −6.1%	Enter above $267.07 (+19.3%)	35% 79/227	+4.7% / +16.9%	−65.6% / −83.6%
Chandelier ExitChuck LeBeau · daily	OUT	Oct 1, 2026 −3.2%	Enter above $255.96 (+14.4%)	36% 76/213	+8.2% / +16.9%	−84.8% / −83.6%
Wilder Volatility SystemJ. Welles Wilder Jr. · daily	OUT	Oct 1, 2026 −3.2%	Enter above $247.21 (+10.5%)	32% 61/189	+0.2% / +16.9%	−88.7% / −83.6%
P&F Double TopA.W. Cohen & Thomas J. Dorsey · daily	OUT	Oct 1, 2026 −3.2%	Enter above $261.01 (+16.6%)	33% 76/233	+2.7% / +16.9%	−79.3% / −83.6%
Chande Kroll StopTushar S. Chande & Stanley Kroll · daily	OUT	Oct 1, 2026 −3.2%	Enter above $244.87 (+9.4%)	29% 96/335	+8.0% / +16.9%	−83.8% / −83.6%
Acceleration BandsPrice Headley · daily	OUT	Sep 8, 2026 −13.9%	Not on one close	31% 49/156	+1.6% / +16.9%	−39.8% / −83.6%
TTM SqueezeJohn F. Carter · daily	OUT	Sep 10, 2026 −9.6%	Not on one close	38% 63/165	+4.3% / +16.9%	−45.5% / −83.6%
NR7 BreakoutToby Crabel · daily	OUT	Sep 30, 2026 −9.3%	Enter above $257.27 (+14.9%)	35% 229/663	+12.6% / +16.9%	−60.4% / −83.6%
Bollinger SqueezeJohn Bollinger · daily	OUT	Oct 24, 2025 −51.7%	Not on one close	34% 13/38	+6.4% / +16.9%	−22.9% / −83.6%
Momentum
12-Month MomentumMoskowitz, Ooi & Pedersen · month-end	OUT	May 29, 2026 −25.9%	Enter above $472.88 (+111.3%)	41% 9/22	+15.3% / +17.6%	−51.4% / −83.6%
12-1 MomentumNarasimhan Jegadeesh & Sheridan Titman · month-end	OUT	Jun 30, 2026 −25.6%	Not on one close	33% 6/18	+14.0% / +17.6%	−68.3% / −83.6%
Dual MomentumGary Antonacci · month-end	OUT	Apr 30, 2026 −27.7%	Enter above $525.80 (+134.9%)	25% 9/36	+8.8% / +17.6%	−78.7% / −83.6%
Stocks on the MoveAndreas F. Clenow · daily	OUT	Jul 31, 2025 −42.9%	Not on one close	26% 26/100	+6.4% / +16.9%	−78.2% / −83.6%
52-Week HighThomas J. George & Chuan-Yang Hwang · month-end	OUT	Dec 31, 2025 −43.7%	Enter above $449.62 (+100.9%)	30% 9/30	+5.7% / +17.3%	−48.5% / −83.6%
Levy Relative StrengthRobert A. Levy · weekly	OUT	Dec 12, 2025 −43.7%	Enter above $279.53 (+24.9%)	31% 27/87	+14.3% / +16.9%	−56.1% / −83.6%
MACD Signal CrossGerald Appel · daily	OUT	Oct 1, 2026 −3.2%	Enter above $244.48 (+9.2%)	38% 153/399	+12.8% / +16.9%	−63.3% / −83.6%
Elder ImpulseAlexander Elder · daily	OUT	Sep 30, 2026 −9.3%	Enter above $231.55 (+3.5%)	31% 233/753	+6.5% / +16.9%	−63.4% / −83.6%
Know Sure ThingMartin J. Pring · daily	OUT	Oct 2, 2026 +1.9%	Enter above $361.82 (+61.7%)	38% 113/297	+4.2% / +16.9%	−64.4% / −83.6%
Coppock CurveEdwin S. C. Coppock · month-end	OUT	Aug 31, 2026 −7.0%	Enter above $461.97 (+106.4%)	28% 5/18	+10.6% / +14.1%	−67.4% / −83.6%
CCI +100Donald R. Lambert · daily	OUT	Sep 10, 2026 −9.6%	Enter above $272.18 (+21.6%)	30% 170/575	+5.3% / +16.9%	−69.3% / −83.6%
TRIX Signal CrossJack K. Hutson · daily	OUT	Oct 2, 2026 +1.9%	Enter above $398.56 (+78.1%)	39% 105/267	+1.6% / +16.9%	−80.1% / −83.6%
TSI Zero LineWilliam Blau · daily	OUT	Oct 1, 2026 −3.2%	Enter above $301.80 (+34.8%)	28% 56/199	+0.9% / +16.9%	−82.9% / −83.6%
13612W MomentumWouter J. Keller & Jan Willem Keuning · month-end	OUT	Sep 30, 2026 −9.3%	Enter above $247.55 (+10.6%)	37% 30/82	+6.2% / +17.6%	−73.9% / −83.6%
Market-State MomentumMichael J. Cooper, Roberto C. Gutierrez Jr. & Allaudeen Hameed · month-end	OUT	Jun 30, 2026 −25.6%	Not on one close	35% 6/17	+12.7% / +14.8%	−68.3% / −83.6%
Frog in the PanZhi Da, Umit G. Gurun & Mitch Warachka · daily	OUT	Jun 30, 2026 −25.6%	Not on one close	38% 12/32	+7.8% / +17.6%	−80.8% / −83.6%
PMO Signal CrossCarl Swenlin · daily	OUT	Oct 1, 2026 −3.2%	Enter above $260.19 (+16.3%)	38% 118/310	+10.0% / +16.5%	−78.3% / −83.6%
Mean reversion
RSI 30/70J. Welles Wilder Jr. · daily	IN	Jan 21, 2026 −38.8%	Not on one close	64% 25/39	+12.2% / +16.9%	−65.3% / −83.6%
RSI(2) PullbackLarry Connors & Cesar Alvarez · daily	OUT	Dec 18, 2025 −43.5%	Not on one close	59% 149/254	+5.4% / +17.4%	−47.3% / −83.6%
Double 7sLarry Connors & Cesar Alvarez · daily	OUT	Jan 6, 2026 −44.9%	Not on one close	61% 196/320	+4.2% / +17.4%	−62.0% / −83.6%
Bollinger ReversionJohn Bollinger · daily	IN	Oct 1, 2026 −3.2%	Sell above $237.71 (+6.2%)	62% 108/173	+5.7% / +16.9%	−55.1% / −83.6%
Stochastic 20/80George C. Lane · daily	IN	Oct 7, 2026 −0.3%	Not on one close	63% 103/164	+8.4% / +16.9%	−60.9% / −83.6%
Williams %RLarry Williams · daily	IN	Oct 6, 2026 −0.1%	Not on one close	63% 179/286	+11.7% / +16.9%	−60.8% / −83.6%
DeMark 9-CountTom DeMark · daily	OUT	Aug 24, 2026 −5.2%	Not on one close	54% 42/78	+13.4% / +16.9%	−54.1% / −83.6%
Mayer MultipleTrace Mayer · daily	IN	Mar 16, 2005 +3,106.6%	Sell above $716.17 (+220.0%)	–	+17.4% / +17.4%	−83.6% / −83.6%
ConnorsRSI PullbackLarry Connors & Cesar Alvarez & Matt Radtke · daily	OUT	Aug 1, 2024 −16.7%	Not on one close	48% 25/52	+1.2% / +16.5%	−41.2% / −83.6%
Laguerre RSIJohn F. Ehlers · daily	OUT	Sep 30, 2026 −9.3%	Enter above $229.24 (+2.4%)	52% 166/322	+19.6% / +16.9%	−51.8% / −83.6%
StochRSI 20/80Tushar S. Chande & Stanley Kroll · daily	IN	Oct 9, 2026 −3.8%	Not on one close	56% 227/407	+8.0% / +16.9%	−75.7% / −83.6%
IBS ReversionAlexander S. Pagonidis · daily	OUT	Oct 13, 2026 0.0%	Buy below $223.82 (0.0%)	58% 1089/1892	+2.7% / +16.9%	−49.4% / −83.6%
Connors %bLarry Connors & Cesar Alvarez · daily	OUT	Jan 7, 2026 −47.0%	Not on one close	57% 42/74	+6.2% / +17.4%	−59.8% / −83.6%
Fisher TransformJohn F. Ehlers · daily	IN	Oct 12, 2026 −1.4%	Exit below $223.24 (−0.3%)	38% 400/1058	+7.2% / +16.9%	−68.6% / −83.6%
1-Month ReversalNarasimhan Jegadeesh & Bruce N. Lehmann · month-end	OUT	Aug 31, 2026 −7.0%	Buy below $251.72 (+12.5%)	62% 86/138	+12.4% / +16.9%	−64.3% / −83.6%
Volume & money flow
On-Balance VolumeJoseph E. Granville · daily	OUT	Oct 13, 2026 0.0%	Enter above $223.82 (0.0%)	27% 200/739	+1.1% / +16.9%	−81.0% / −83.6%
Chaikin Money FlowMarc Chaikin · daily	OUT	Oct 1, 2026 −3.2%	Not on one close	39% 86/218	+5.2% / +16.9%	−73.6% / −83.6%
Money Flow IndexGene Quong & Avrum Soudack · daily	OUT	Jul 10, 2026 −25.1%	Not on one close	58% 30/52	+13.6% / +16.9%	−52.2% / −83.6%
Negative Volume IndexNorman Fosback & Paul Dysart · daily	OUT	Jan 8, 2026 −44.0%	Not on one close	36% 46/128	+14.6% / +17.5%	−65.4% / −83.6%
Force IndexAlexander Elder · daily	OUT	Sep 29, 2026 −11.9%	Enter above $235.22 (+5.1%)	26% 181/685	+5.3% / +16.9%	−78.5% / −83.6%
Buff AveragesBuff Dormeier · daily	OUT	Oct 1, 2026 −3.2%	Enter above $285.38 (+27.5%)	33% 127/385	+2.0% / +16.9%	−82.6% / −83.6%
Chaikin OscillatorMarc Chaikin · daily	OUT	Oct 1, 2026 −3.2%	Enter above $223.82 (+0.0%)	36% 213/588	+14.4% / +16.9%	−62.4% / −83.6%
Volume Flow IndicatorMarkos Katsanos · daily	OUT	Sep 9, 2026 −13.2%	Not on one close	31% 31/100	+14.0% / +17.6%	−60.4% / −83.6%
Klinger OscillatorStephen J. Klinger · daily	OUT	Oct 12, 2026 −1.4%	Buy $225.55–$300.35 (+0.8%)	35% 329/929	+1.1% / +16.9%	−65.8% / −83.6%
Candles & chart patterns
Engulfing SwitchSteve Nison & Thomas N. Bulkowski · daily	OUT	Jun 10, 2026 −23.1%	Enter above $228.93 (+2.3%)	47% 76/161	+8.8% / +16.9%	−67.3% / −83.6%
HikkakeDaniel L. Chesler · daily	OUT	Jul 17, 2026 −16.3%	Not on one close	35% 35/100	+7.5% / +16.9%	−66.6% / −83.6%
Turtle Soup Plus OneLinda Bradford Raschke & Larry Connors · daily	OUT	Jun 18, 2026 −19.5%	Not on one close	43% 33/76	+1.8% / +16.9%	−53.9% / −83.6%
Calendar
Halloween IndicatorSven Bouman & Ben Jacobsen & Yale Hirsch & Jeffrey Hirsch · daily	OUT	Apr 30, 2026 −27.7%	Buys Oct 30	44% 19/43	+2.3% / +16.9%	−68.1% / −83.6%
Best Six + MACDYale Hirsch & Jeffrey Hirsch · daily	OUT	Apr 17, 2026 −27.7%	Enter above $229.97 (+2.7%)	44% 19/43	+2.3% / +16.9%	−73.5% / −83.6%
Seasonal TimingSy Harding · daily	OUT	Apr 20, 2026 −28.0%	Window opens Oct 16	42% 18/43	+1.2% / +16.9%	−70.5% / −83.6%
Santa Claus RallyYale Hirsch & Jeffrey Hirsch · daily	OUT	Jan 5, 2026 −43.7%	Buys Dec 23	43% 19/44	+2.6% / +16.9%	−25.0% / −83.6%
Turn of the MonthJosef Lakonishok & Seymour Smidt & Robert A. Ariel · daily	OUT	Oct 5, 2026 +1.8%	Buys Oct 29	51% 270/526	+4.7% / +16.9%	−71.0% / −83.6%
Presidential Sweet SpotYale Hirsch & Jeffrey Hirsch · daily	IN	Sep 30, 2026 −9.3%	Sells Jun 30	36% 4/11	+0.8% / +16.9%	−53.0% / −83.6%
Pre-HolidayRobert A. Ariel & Josef Lakonishok & Seymour Smidt · daily	OUT	Sep 4, 2026 −15.9%	Buys Nov 24	51% 203/400	+4.2% / +16.9%	−16.9% / −83.6%
January BarometerYale Hirsch & Jeffrey Hirsch · month-end	IN	Dec 30, 2022 −5.8%	Not on one close	40% 8/20	+16.8% / +16.9%	−58.7% / −83.6%
Weekend EffectKenneth French & Josef Lakonishok & Seymour Smidt · daily	IN	Oct 12, 2026 −1.4%	Sells Oct 16	52% 1177/2284	+6.5% / +16.9%	−85.6% / −83.6%
Pre-FOMC DriftDavid Lucca & Emanuel Moench · daily	OUT	Sep 16, 2026 −6.5%	Buys Oct 27	50% 174/348	+4.2% / +16.9%	−34.8% / −83.6%
Lunar CycleKathy Yuan, Lu Zheng & Qiaoqiao Zhu · daily	IN	Oct 2, 2026 +1.9%	Sells Oct 16	50% 272/541	+7.2% / +16.9%	−80.9% / −83.6%
Benchmark
Buy & HoldJohn C. Bogle · benchmark	IN	Jan 3, 2005	Always in	–	+16.9%	−83.6%

If the market cracks: the storm test

How the storm test works

ExposureModerate4 of 10 points

Market swings1/3
Past crashes0/2
Debt3/3
Run-up0/2

It carries 3.8× as much debt as equity.
It operating profit covers interest only 2.3×.

Past crashes, peak to low

Financial crisis Oct 2007 to Mar 2009 · back to its old high Jul 2013

ALNY−59%

S&P 500−57%

COVID crash Feb 2020 to Mar 2020 · back to its old high Apr 2020

ALNY−28%

S&P 500−34%

2022 bear market Jan 2022 to May 2022 · back to its old high Aug 2022

ALNY−31%

S&P 500−25%

Beta0.96Moves about 1.0× as much as the S&P 500 week to week.
Downside capture256%In months the S&P 500 fell, this fell 256% as much on average.
Two-year change−21%
From 52-week high−54%
Debt to equity3.79×
Net debt / EBITDANet cashHolds more cash than debt.
Interest cover2.3×

A crash marks every stock down; debt decides which companies come through. The storm test scores both halves: how hard the stock swings with the market, and how much debt it carries into a downturn. It describes fragility; it does not predict a crash.

The business behind the price

How to judge these numbers

Biotechnology · Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. The company offers ONPATTRO for hereditary transthyretin-mediated (hATTR) amyloidosis; AMVUTTRA for ATTR and hATTR amyloidosis; Leqvio for hypercholesterolemia; Qfitlia for hemophilia A or B; GIVLAARI for acute hepatic porphyria; and OXLUMO for primary hyperoxaluria type 1.

Size and valuation
Market cap	$29.9B	What the whole company is worth at today's price: share price × shares outstanding.
Revenue (last 12 months)	$4.8B	Total sales. The market values it at 6.2× sales.
P/E ratio	37.7×	Buyers pay $38 for each $1 of the last year's profit.
Forward P/E	17.9×	Price against analysts' estimate of next year's profit. Lower than the P/E means profit is expected to grow.
Price to book	22.1×	Price against the company's net assets (its equity) per share.

Profit and growth
Profit margin	16.1%	Keeps 16¢ of each dollar of sales as profit.
Revenue growth	+66.9%	Last quarter's sales against the same quarter a year earlier.
Return on equity	59.7%	Yearly profit as a share of shareholders' money in the business.
Free cash flow	$272M	Cash left after running and investing in the business.

Balance sheet
Total equity	$789M	What it owns minus what it owes.
Total debt	$3.0B	Loans and bonds it has to pay back, with interest.
Cash	$3.3B	Cash and short-term investments on hand.
Debt to equity	3.79×	Above about 1.5× is heavily borrowed; above 3× is fragile in a downturn.
Interest cover	2.3×	Operating profit divided by interest. Under 2× means one bad year could make the interest hard to pay.

Wall Street
Average analyst target	$370.55	66% above the close, from 26 analysts (range $256.00 to $536.00).
Consensus rating	Buy	Analysts' average recommendation. Ratings lean positive: sell ratings are rare.

P/E, price to sales and book, growth, margin and return on equity from the company's SEC filings for the quarter to 2026-06-30; other company figures from Yahoo Finance, fetched Oct 14, 2026. Analyst targets are opinions, not forecasts Be The Puck checks.

Reports for Be The Puck Members.

ALNY: the briefWhat the plays, the levels and the business say, in plain English. Rebuilt nightly.Members Healthcare: what the plays sayEvery covered name in the sector, side by side.Members Debt decides who survives a crashThe storm test on every covered stock.Members Is this a bubble?The gauges in October 2026, and what history says about timing.Members

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